| 摘要 |
The present invention provides compositions and methods for the treatment of cardiovascular diseases. More particularly, the present invention relates to modifying thrombus formation by administering an agent which, inter alia, is capable of (1) inactivating fluid-phase thrombin and thrombin which is bound either to fibrin in a clot or to some other surface by catalyzing antithrombin; and (2) inhibiting thrombin generation by catalyzin g factor Xa inactivation by antithrombin III (ATIII). The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at ri sk of suffering from thrombus-related cardiovascular conditions, such as unstab le angina, acute myocardial infarction (heart attack), cerebrovascular accident s (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc . |
