发明名称 |
Non-human transgenic animals deficient in gas6 function and their use |
摘要 |
It has been shown that Gas6 deficient endothelial cells are resistant to activation by endotoxin and TNF- alpha <i>in vitro</i> and <i>in vivo</i> and that leukocytes did not or much less extravasate in Gas6 deficient mice. The present invention also relates to the manufacture of a medicament for the treatment of endothelial dysfunction. The present invention further relates to the use of an inhibitor of the Gas6 function and/or an inhibitor of a Gas6 receptor for the manufacture of said medicament. |
申请公布号 |
AU5077100(A) |
申请公布日期 |
2001.01.02 |
申请号 |
AU20000050771 |
申请日期 |
2000.06.08 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
PETER CARMELIET;DESIRE COLLEN;BJORN DAHLBACK;PABLO GARCIA DE FRUTOS;CRISTINA APARICIO |
分类号 |
A01K67/027;A61K38/17;A61K39/395;A61P9/00;C07K14/745;C12N15/00;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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