| 摘要 |
Degradable cross-linkers which are used to form polymer networks which degra de under aqueous conditions are described. These cross-linkers comprise a monodispersed central polyacid, monodispersed monomeric or monodispersed oligomeric degradable regions and an optional water soluble regions. These monomers are preferably polymerized using free radical or condensation polymerization. Degradation occurs at degradable regions such as ester linkages after cross-linking polymer filaments, and results in soluble polym er filaments which may be cleared from the body. Preferred applications of thes e materials include, for example, controlled release of drugs and cosmetics, tissue engineering, wound healing, hazardous waste remediation, metal chelation, swellable devices for absorbing liquids and the prevention of surgical adhesions. |
