发明名称 |
Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
摘要 |
A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability. |
申请公布号 |
AU5936400(A) |
申请公布日期 |
2000.12.28 |
申请号 |
AU20000059364 |
申请日期 |
2000.06.02 |
申请人 |
DELRX PHARMACEUTICAL CORPORATION;RANDALL E MCCOY;MILES AUGUSTUS LIBBEY III;JIE LIU;ROBERT O. WILLIAMS III |
发明人 |
RANDALL E MCCOY;MILES AUGUSTUS LIBBEY III;JIE LIU;ROBERT O. WILLIAMS III |
分类号 |
A61K9/12;A61K9/00;A61K9/10;A61K9/14;A61K9/19;A61K38/00;A61K38/28;A61K47/10;A61K47/14;A61K47/20;A61K47/22;A61K47/26;A61K47/32;A61K47/34;A61L9/04;A61P3/10;A61P5/48 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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