| 摘要 |
<p>A method of enhancing protective immunity induced by any polynucleotide vaccine or combination of polynucleotide vaccines comprising immunizing with a priming immunization mixture of a polynucleotide vaccine mixed with a polynucleotide vector that expresses a cytokine. Subsequently the priming vaccination is followed by immunizing with a boosting immunization preparation that contains a recombinant pox virus. This method also reduces the amount of vaccine needed to achieve protective immunity and broadens the coverage in a vaccinated population.</p> |
