NOVEL ECHINOCANDIN DERIVATIVES, METHOD FOR PREPARING SAME AND USE AS ANTIFUNGAL AGENTS

摘要

The invention concerns compounds of formula (I) wherein: either R1 and R2 = H, OH, alkyl optionally substituted, or NR1 forms with the carbon bearing NR1R2 a double bond and R2 is XRa, X being O, NH or N-alkyl and Ra being H, alkyl optionally substituted, or R2 is e-N = C(-N-d)-N(f)-g; R3 = H, OH, CH3; R4 = H, OH; R = chain containing up to 30 carbon atoms, optionally containing one or several heteroatoms, one or several heterocycles; T = H, CH3, CH2CONH2, CH2C≡N, (CH2)2NH2, (CH2)2Nalk<+>X<->; Y = H, OH, halogen, OSO3H; W = H, OH; Z = H or CH3. The products have antifungal properties.