发明名称 |
ETHANESULFONYL-PIPERIDINE DERIVATIVES |
摘要 |
The invention relates to compounds of general formula (I) wherein R signify hydrogen or hydroxy; R<2> signify hydrogen or methyl; and X signify -O- or -CH2-; and their pharmaceutically acceptable acid addition salts. It has been shown that these compounds have a good affinity to the NMDA receptor and they are therefore useful in the treatment of diseases, wherein the therapeutic indications include acute forms of neurodegeneration caused, e.g., by stroke or brain trauma; chronic forms of neurodegeneration such as Alzheimer's disease, Parkinsons's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis); neurodegeneration associated with bacterial or viral infections, and, diseases such as schizophrenia, anxiety, depression and chronic/acute pain.
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申请公布号 |
WO0075109(A1) |
申请公布日期 |
2000.12.14 |
申请号 |
WO2000EP04953 |
申请日期 |
2000.05.31 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ALANINE, ALEXANDER;BURNER, SERGE;BUETTELMANN, BERND;HEITZ NEIDHART, MARIE-PAULE;JAESCHKE, GEORG;PINARD, EMMANUEL;WYLER, RENE |
分类号 |
A61K31/445;A61P21/00;A61P25/00;A61P25/04;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;C07D211/14;C07D211/30;C07D211/42;C07D211/44;C07D211/46;(IPC1-7):C07D211/46 |
主分类号 |
A61K31/445 |
代理机构 |
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