CRYSTALLINE ADDITIVE SALTS OF 7-ALPHA[(2-AMINOTHIAZOL-4-YL)- -ALPHA-(Z)-METHOXYIMINOACETAMIDO]-3-[(1-METHYL-1- -PYRROLIDINO)METHYL]-3-CEPHEM-4-CARBOXYLATE, METHOD FOR PRODUCING AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

摘要

Disclosed is a crystalline 7-[alfa-(2-amino-thiazole-4-yl)- alfa-(Z)-methoxy-imine-acetamide]-3-[(1-methyl-1- pyrolidine)methyl]-3-cephem-4-carboxylate-dichlorine-hydrate which contains weight 2.5 to 7.0 % of water, and has diagram of X-ray powder difraction listed in description. Disclosed is also physical mixture containing it and L(+)-lysine or L(+)-agrinine and pharmaceutical substance with antibiotic effect containing it, which contains also pharmaceutically acceptable non-toxical, organic or anorganic alkalis of amount to set up the pH value 3.5 to 7 after dilution with water to injectable concentration.