FIBRIN SEALANTS PROVIDING LESS INFLAMMATORY RESPONSE AND METHODS USING SAME

摘要

In accordance with the present invention novel fibrin sealants which provoke less of any inflammatory response than prior art sealants, and methods of using such sealants, are disclosed. It has now been found that fibrin sealan ts can be prepared in a number of ways to selectively include or exclude components which are presently understood to upregulate or downregulate the body's natural inflammatory response. The novel sealants of this invention a re useful in any instance where fibrin sealants have known utility. Nonlimiting examples include use in hemostasis, sealing of fluid or air leaks, delivery of cells, tissue repair and wound healing, drug delivery and particularly usefu l in the prevention of post surgical adhesion formation.