| 摘要 |
A medication delivery device for delivering a small molecule insulin mimetic material to a body of an individual includes a housing, a reservoir and a controller. The housing contains a driving mechanism, and the reservoir is coupled to the driving mechanism in the housing for holding the small molecule insulin mimetic material to be infused into the body of the individual. The controller controls the driving mechanism to expel the small molecule insulin mimetic material from the reservoir into the body of the individual. Preferably, the medication delivery device is an infusion pump. In particular, the driving mechanism is a syringe type drive actuator, or a gas generator. The driving mechanism may also utilize iontophoresis or passive trans-dermal delivery. In addition, the driving mechanism is controlled to infuse the small molecule insulin mimetic material in a continuous, near-continuous, intermittent and pulsatile manner. The driving mechanism may also be controlled to deliver discrete, user settable boluses. Preferably, the small molecule insulin mimetic material is L-783,281. Also, the small molecule insulin mimetic material may be an analog of L-783,281. In addition, the small molecule insulin mimetic material may be infused with at least one additional component such as insulin, insulin analogs and insulin related peptides. Preferably, the small molecule insulin mimetic material binds to < sub-units of an insulin receptor site. However, the small molecule insulin mimetic material may bind to alpha sub-Units of an insulin receptor site. Alternatively, the small molecule insulin mimetic material is a trans-membrane insulin mimetic material that binds to at least one ? sub-unit and at least one ? sub-unit of an insulin receptor site.
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