| 摘要 |
PCT No. PCT/SE97/01504 Sec. 371 Date Dec. 18, 1997 Sec. 102(e) Date Dec. 18, 1997 PCT Filed Sep. 8, 1997 PCT Pub. No. WO98/11102 PCT Pub. Date Mar. 19, 1998The present invention provides novel compounds of the formula (I): R20-(CH2)n-R(I) wherein: T20 is a bisindolylmaleimide moiety linked to the -(CH2)n-group through an indolyl nitrogen, n is 0 or 1, R is a 5 or 6 membered aromatic carbocyclic or heterocyclic ring, the heterocyclic ring containing N or S, R is substituted by R1 and up to four of R2, R3, R4 and R5, wherein; R1 is aminomethyl, (N-(C1-4-alkyl)amino)methyl, (N,N-di(C1-4-alkyl)amino)methyl or pyridiniummethyl, and R2, R3, and R4 and R5 (if present), which may be the same or different, are each hydrogen, hydroxy, C1-4-alkoxy, C1-4-alkoxy) or halogen, or R2 when in a position contiguous to the bond connecting R to the -(CH2)n- group and n is 1 may, together with the 2-carbon atom on the indole to which the -(CH2) group is attached, form a ring, and pharmaceutically acceptable salts thereof; and the use of such compounds in medical therapy.
|
