Carbostyril derivatives

摘要

PCT No. PCT/JP96/02892 Sec. 371 Date May 29, 1998 Sec. 102(e) Date May 29, 1998 PCT Filed Oct. 4, 1996 PCT Pub. No. WO97/12869 PCT Pub. Date Apr. 10, 1997A carbostyril derivative of the formula (1): wherein A is lower alkylene, R is H, halogen or lower alkoxy, R1 and R2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R3 are H, R1 and R2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.