发明名称 Carbamic acid derivatives and their use as metabotropic glutamate receptor ligands
摘要 The present invention is a compound of formula:wherein R1, R2, R2', X, A1/A2 and B are as defined in the specification.These compounds may be used in the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease, Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, memory deficits, schizophrenia, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, acute and chronic pain, dyskinesia and depression.
申请公布号 AU4749200(A) 申请公布日期 2000.11.02
申请号 AU20000047492 申请日期 2000.04.19
申请人 F.HOFFMANN-LA ROCHE AG 发明人 KONRAD BLEICHER;VINCENT MUTEL;ERIC VIEIRA;JURGEN WICHMANN;THOMAS JOHANNES WOLTERING
分类号 C07D295/08;A61K31/325;A61K31/352;A61K31/381;A61K31/382;A61K31/421;A61K31/422;A61K31/4245;A61K31/4409;A61K31/5375;A61P25/00;A61P25/06;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/34;A61P27/02;C07C233/90;C07C233/91;C07C271/64;C07C333/10;C07D213/00;C07D213/30;C07D213/60;C07D213/61;C07D263/48;C07D271/00;C07D271/06;C07D271/07;C07D271/10;C07D271/113;C07D295/088;C07D311/84;C07D333/16;C07D335/12;C07D335/14;C07D409/12;C07D413/12;(IPC1-7):C07C271/64;A61K31/424 主分类号 C07D295/08
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