The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants.
申请公布号
WO0061758(A1)
申请公布日期
2000.10.19
申请号
WO2000AU00294
申请日期
2000.04.07
申请人
NORTH WESTERN HEALTH CARE NETWORK;SMITHKLINE BEECHAM CORPORATION;BARTHOLOMEUSZ, ANGELINE;LITTLEJOHN, MARGARET;AYRES, ANNA;LOCARNINI, STEPHEN
发明人
BARTHOLOMEUSZ, ANGELINE;LITTLEJOHN, MARGARET;AYRES, ANNA;LOCARNINI, STEPHEN