发明名称 |
Processes and intermediates for the preparation of piperazine derivatives |
摘要 |
Compounds having the formulaR5O-A-NR4-R2(V)where R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent -SO- or -SO2- and A is C2-C4 alkylene optionally substituted by one or more lower alkyl groups are novel intermediates in the preparation of pharmaceutically useful piperazine derivatives as end compounds. The compounds having formula V where R4 and R5 are hydrogen may be prepared by a rearrangement of a compound having the formula (VI).R2O-A-NH2(VI)
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申请公布号 |
US6133449(A) |
申请公布日期 |
2000.10.17 |
申请号 |
US19980012066 |
申请日期 |
1998.01.22 |
申请人 |
JOHN WYETH & BROTHER LTD. |
发明人 |
BRIGHTWELL, CHRISTOPHER IAN;SHEPHERD, ROBIN GERALD |
分类号 |
C07D213/74;C07D401/12;C07D419/04;(IPC1-7):C07D213/42 |
主分类号 |
C07D213/74 |
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