COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS

摘要

Compounds of formula (I), (υ) wherein the dotted line represents an optional bond; and the pharmaceutically acceptable salts thereof, wherein X1 is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR¿2?, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or =O, or by one or more aliphatic or aromatic 5-or 6-membered rings optionally containing 1-2 heteroatoms; R?1¿ is (a). These compounds are selective inhibitors of p38α kinase.