| 摘要 |
PROBLEM TO BE SOLVED: To selectively obtain an N-substituted cyclic amidine in a high yield without requiring a special reactor vessel by reacting a specific cyclic amidine with a carbonic acid diester, while removing the by-product carbon dioxide outside the system. SOLUTION: This method for producing an N-substituted cyclic amidine comprises reacting (A) a cyclic amidine of the formula [R is a (OH-substituted) 1-20C monovalent hydrocarbon or H; Q is a (substituted) 2-10C divalent hydrocarbon] (for example, an imidazole) and having an active hydrogen atom bound to a nitrogen atom constituting the heterocylic group, preferably selected from among imidazole derivatives, imidazoline derivatives and pyrimidine derivatives, with (B) a carbonic acid diester (preferably 2-8C dialkyl ester) (for example, diethyl carbonate) in an A/B reaction molar ratio of 1/5 to 1/1, if necessary, in a solvent (preferably an aprotic solvent) (for example, tetrahydrofuran), while the by-produced carbon dioxide gas is removed outside the system. |
