HUMAN PAPILLOMAVIRUS VACCINE WITH DISASSEMBLED AND REASSEMBLED VIRUS-LIKE PARTICLES
摘要
Human Papillomavirus vaccine formulations which contain virus-like particles (VLPs) can be made more stable and have an enhanced shelf-life, by treating the VLPs to a disassembly and reassembly process. Also provided are formulation buffers to long term stable storage of VLPs.
申请公布号
WO0057906(A1)
申请公布日期
2000.10.05
申请号
WO2000US07595
申请日期
2000.03.22
申请人
MERCK & CO., INC.;VOLKIN, DAVID, B.;MACH, HENRYK;SHI, LI