| 摘要 |
<p>By analyzing a mechanism of the expression of cyclin-CDK inhibitory factor having a proliferation inhibitory effect (carcinostatic effect) induced by a histone deacetylase inhibitor (Trichostatin A), it is found out that binding of Sp3 to the Sp1 binding sequence contained in a promoter is important in the expression of the above factor. Thus, a novel antitumor agent can be developed by screening a drug capable of elevating the Sp3 activity.</p> |
