摘要 |
PCT No. PCT/US96/20872 Sec. 371 Date Sep. 16, 1998 Sec. 102(e) Date Sep. 16, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23216 PCT Pub. Date Jul. 3, 1997Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs are selective active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, psychosis, anxiety, migraine headaches, glaucoma, CMV retinitis, aminoglycoside antibiotics-induced hearing loss, convulsions, chronic pain, opioid tolerance or withdrawal, urinary incontinence or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
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申请人 |
WARNER-LAMBERT COMPANY;COCENSYS, INCORPORATED |
发明人 |
BIGGE, CHRISTOPHER F.;YUEN, PO-WAI;CAI, SUI XIONG;WEBER, ECKARD;WOODWARD, RICHARD;LAN, NANCY C.;ZHOU, ZHANG-LIN;KEANA, JOHN F. W.;GUZIKOWSKI, ANTHONY P. |