NOVEL PHOSPHATE AND THIOPHOSPHATE PROTECTING GROUPS

摘要

Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more internucleosidic phosphorus functionalities, preferably followed by oxidation and cleavage of the protecting groups to provide oligonucleotides. The figure shows nucleoside phosphoramidites bearing [2-[N-isopropyl-N-(4-methoxybenzoyl) amino] ethyl] phosphate protecting groups.