发明名称 |
Inhibitors of prenyl-protein transferases |
摘要 |
The present invention comprises piperazine-containing compounds which inhibit prenyl-protein transferases. In particular, the invention relates to prenyl-protein transferase inhibitors which are efficacious in vivo as inhibitors of geranylgeranyl-protein transferase type I (GGTase-I) and that inhibit the cellular processing of both the H-Ras protein and the K4B-Ras protein. Such therapeutic compounds are useful in the treatment of cancer. |
申请公布号 |
AU3248600(A) |
申请公布日期 |
2000.09.21 |
申请号 |
AU20000032486 |
申请日期 |
2000.03.01 |
申请人 |
MERCK & CO., INC. |
发明人 |
CRAIG A. STUMP;THERESA M. WILLIAMS |
分类号 |
A61P9/10;A61P13/12;A61P27/02;A61P31/14;A61P35/00;C07D233/54;C07D401/12;C07D405/12 |
主分类号 |
A61P9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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