| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject new compound capable of expressing useful antimicrobial activity through strongly binding to a DNA, therefore useful for treating Pneumocystis carini pneumonia. SOLUTION: This new compound is a compound of formula I (R1 and R2 are each H, a lower alkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, a halogen, or the like; R3 and R4 are each H, a lower alkyl, oxyalkyl, alkylaryl, aryl, or the like; X and Y are each located at a p- or m-site, being H, a lower alkyl, oxyalkyl, or the like), e.g. 2,4-bis 4-[(amidino)phenyl]}furan. The compound of formula I is synthesized, for example, by reacting a compound of formula II in the presence of a base to form a compound of formula III (X is a halogen, pref. Br or I), which is then reacted with CuCN in the presence of DMF to form 2,4-bis(4-cyanophenyl)furan as its important intermediate. It is prefarable to use the compound of formula I at a dose of 0.1-50 m/kg.
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