| 摘要 |
The present invention provides domain 1 beta 2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 beta 2GPI polypeptides and mimetics. Domain 1 of beta 2GPI has been shown to bind to anti-cardiolipin ( beta 2GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 beta 2GPI polypeptides may be used to detect beta 2GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 beta 2GPI polypeptides.
|
| 申请人 |
LA JOLLA PHARMACEUTICAL COMPANY;MARQUIS, DAVID, M.;IVERSON, GILBERT, M.;VICTORIA, EDWARD, J.;JONES, DAVID, S.;LINNIK, MATTHEW, D. |
发明人 |
MARQUIS, DAVID, M.;IVERSON, GILBERT, M.;VICTORIA, EDWARD, J.;JONES, DAVID, S.;LINNIK, MATTHEW, D. |
