The present invention is directed to compounds which inhibit prenyl-protein transferase and particularly, the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
申请公布号
WO0034239(A3)
申请公布日期
2000.09.08
申请号
WO1999US29175
申请日期
1999.12.07
申请人
MERCK & CO., INC.;DESOLMS, S., JANE;SHAW, ANTHONY, W.