Substituted phenols and thiophenols useful as antioxidant agents

摘要

The present invention provides compounds of the formula wherein X is selected from the group consisting of Y is thio, oxy or a methylene group; Z is hydrogen or -C(O)-(CH2)m-Q wherein Q is hydrogen or -COOH and m is an integer 1, 2, 3 or 4; R1 is C1-C6 alkyl; and R2, R3 and R4 are each independently hydrogen or C1-C6 alkyl; or a stereoisomer thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.