| 摘要 |
medicinal industry. SUBSTANCE: method involves separate granulation of acetylsalicylic acid, ascorbic acid and dimedrol used as active components by their wetting with film-forming agent. Then granulates are dried, subjected for dry granulation, aerosil is added and mixture is stirred. Polyvinylpyrrolidone as 10-12% ethanol solution is used as film-forming agent. Before granulation components are dried preliminary at 38-40 C. Before granulation and after dry granulation 2-3% of aerosil (of components mass) is added to each granulate. Then granules of calcium lactate and accessory substances (microcrystalline cellulose, starch, citric acid, mannitol) are added. Ethyl alcohol in concentration 96% is used as wetting agent. Then granules are dried and stirred with mixture of early prepared granulates. EFFECT: improved stability of granules. 5 tbl, 3 ex
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