Stabilization of lipid:DNA formulations during nebulization
摘要
The present invention provides a liposomal aerosol composition, comprising a pharmaceutical compound, a cationic lipid, (c) a neutral co-lipid; and (d) tryptone. Also provided is a nebulized cationic lipid:DNA suspension useful for lipid-DNA transfections, wherein said cationic lipid is bis(guanidinium)-tren-cholesterol.
申请公布号
US6106859(A)
申请公布日期
2000.08.22
申请号
US19990227648
申请日期
1999.01.08
申请人
DENSMORE, JR., CHARLES L.;KNIGHT, J. VERNON;WALDREP, J. CLIFFORD;KINSEY, BERMA M.
发明人
DENSMORE, JR., CHARLES L.;KNIGHT, J. VERNON;WALDREP, J. CLIFFORD;KINSEY, BERMA M.
