| 摘要 |
PROBLEM TO BE SOLVED: To provide a medical material with an especially high biocompatibity by incorporating a gel formed from hyaluronic acid alone into the same. SOLUTION: The gel is a self-crosslinked one formed from hyaluronic acid alone without using any other crosslinker or modifier and without forming a composite with a cationic polymer, Preferably, the gel is crushed with a suitable crusher to an average particle size of 10 mm or smaller. The resultant particulate hyaluronic acid gel is neutralized with a phosphoric-acid-buffered physiological salt solution which has a pH of 7 and is prepared by adding a phosphoric acid buffer component in a concentration of 50 mM to a physiological salt solution. The neuralized particulate gel is washed with water for injection and then suspended in a concentration of 0.1-5 wt.% in an arbitrary solution, giving a gel slurry, The slurry is suitable for in-vivo decomposable medical materials, cosmetics, etc. |
