| 摘要 |
The present invention relates to compounds of formula (1) and pharmaceutical ly acceptable salts and solvates thereof wherein R1, R2, R3, R4, R5, R6, R7, R8 , R9, and Z are as defined herein. The invention also relates to pharmaceutica l compositions comprising compounds of formula (1) and to methods of inhibitin g abnormal cell growth, including cancer, in a mammal by administering compoun ds of formula (1) to the mammal. The invention also relates to intermediates an d methods useful in synthesizing compounds of formula (1).
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