4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-B]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY

摘要

The invention concerns compounds of general formula (I) in which: X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group; Y represents a hydrogen atom, one or two halogen atoms or a methyl, hydroxy, methoxy or nitro group; R1 represents a hydrogen atom or a (C1-C4) alkyl group; R2 and R3 represent each, independently of each other, a hydrogen atom, a (C1-C4) alkyl group or a phenyl-methyl group; or R2 and R3 form, together with the nitrogen atom bearing them, an azetidinyl, pyrrolidinyl, 3-ethoxy-pyrrolidinyl, piperidinyl, morpholinyl, 4-methylpiperazinyl or 1,3-thiazolidinyl group. They can be used for treating diseases related to GABAergic transmission disorders.