REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE BREAST

摘要

A set of contiguous and partially overlapping cDNA sequences and polypeptide s encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging , monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions o f the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.