| 摘要 |
PURPOSE: Provided is 1H-pyrido£3,4-b|indole-4-carboxamide derivatives, their preparation and their application in therapeutics. CONSTITUTION: A compound having general formula (I) in which X represents a hydrogen or halogen atom or a (C1 -C3)alkyl, (C1 -C3)alkoxy, trifluoromethyl or phenylmethoxy group, R1 represents a hydrogen atom or a (C1 -C3)alkyl, cyclopropyl or phenylmethyl group, R2 represents either a (C1 -C3)alkyl group optionally substituted by a methoxy group, or a phenyl(C1 -C3)alkyl group optionally substituted on the phenyl ring by a halogen atom or a methyl or methoxy group, or a cyclohexylmethyl group, or a thienylmethyl group, or a pyridinylmethyl group, or a phenyl group optionally substituted by one or more halogen atoms or a (C1 -C3)alkyl or (C1 -C3)alkoxy group, or a pyridinyl group, or a 5-methyl-1,2-oxazolyl group, or a 5-methyl-1,3, 4-thiadiazolyl group, or a naphthyl group, R3 and R4, independently of one another, each represent a hydrogen atom, a (C1 -C3)alkyl group, a 2-methoxyethyl group, a hydroxy(C2 -C4) alkyl group, a carboxy-(C1 -C3)alkyl group, a (C1 -C3)alkoxycarbonyl(C1 -C3)alkyl group or a phenyl(C1 -C3)alkyl group, or else together form, with the nitrogen atom which carries them, either a pyrrolidinyl group optionally substituted by a hydroxyl, ethoxy, methoxycarbonyl or methoxymethyl group, or a piperidinyl group, or a morpholinyl group, or a 4-methylpiperazinyl group, or an azetidinyl group, or a thiazolidinyl group, and the bond between the carbon atoms in the 3 and 4 positions is single or double.
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