| 发明名称 |
TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES |
| 摘要 |
Compounds of formula (I) are poly(ADP-ribosyl)transferase (PARP) inhibitors, and are useful as therapeutics in treatment of cancers and the amelioration of the effects of stroke, head trauma, and neurodegenerative disease. As cancer therapeutics, the compounds of the invention may be used, e.g., in combinati on with cytotoxic agents and/or radiation.
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| 申请公布号 |
CA2360003(A1) |
申请公布日期 |
2000.07.20 |
| 申请号 |
CA20002360003 |
申请日期 |
2000.01.10 |
| 申请人 |
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED;AGOURON PHARMACEUTICALS, INC. |
发明人 |
WEBBER, STEPHEN EVAN;THORESEN, LARS HENRIK;TIKHE, JAYASHREE;CANAN-KOCH, STACIE S. |
| 分类号 |
A61K;A61K31/437;A61K31/4375;A61K31/55;A61K31/551;A61P;A61P3/10;A61P9/10;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07D;C07D209/00;C07D221/00;C07D223/00;C07D243/00;C07D471/06;C07D487/00;C07D487/06;C07D519/00;(IPC1-7):C07D471/06 |
主分类号 |
A61K |
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