COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND INHIBITORS OF GARET, METHOD OF INHIBITION AND PROLIFERATION AND DERIVATIVES OF THIOPHENE CARBOXYLIC ACID ESTER

摘要

organic chemistry, pharmacy. SUBSTANCE: invention describes the novel compounds of the general formula (I) where A means CH2 or S; Z means C1-C3-alkylene; X means C1-C6-alkyl and R1 and R2 mean hydrogen atom. Compounds of the formula (I) existing in equilibrium with their 4-hydroxy-tautomers and in forms of diastereomeric mixtures and their pharmaceutically acceptable salts are strong inhibitors of GARET. These compounds and their salts are useful antiproliferative agents also. Invention describes also method of inhibition and proliferation and derivatives of thiophene carboxylic acid ester. EFFECT: improved method of inhibition and proliferation, valuable pharmacological properties. 14 cl, 3 tbl, 2 ex