| 摘要 |
PURPOSE: A microgranule containing stabilized 5-pirrolyl-2-pyridylmethylsulfinylbenzimidazole derivative (formula 1) is useful as anti-ulcer agent and very unstable in acid is provided. The microgranule uses alkali compound as stabilizer and water soluble high polymer as binder to maximize stability thereof. CONSTITUTION: A microgranule contains 5-pirrolyl-2-pyridylmethylsulfinylbenzimidazole derivative as effective component, 0.2-7.0 times of alkali compound as stabilizer based on molar amount of the effective component and 0.1-50 wt.% of water soluble high polymer as binder based on the total weight of microgranule. The water soluble high polymer can be hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium alginate, alginic acid etc.. The alkali compound can be magnesium oxide, sodium phosphate dibasic, sodium phosphate monobasic, magnesium hydroxide, aluminium hydroxide, aluminium carbonate etc.. The microgranule having maximized stability enables the effective component to be stored at room temperature while transporting for industrial use.
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