A novel F-WD protein which is useful in, for example, treating, preventing or diagnosing diseases induced by the acceleration or depression of protein decomposition; a DNA encoding this protein; an antibody recognizing this protein; and an oligonucleotide comprising a part of the sequence of the DNA. An F-WD protein having the amino acid sequence represented by SEQ ID NO:1; a process for producing this protein; a DNA encoding this protein; an oligonucleotide comprising a part of the sequence of this DNA; a recombinant vector containing this DNA; a transformant carrying this recombinant vector; an antibody recognizing the above protein; a method for quantitating the protein and an immunostaining method with the use of this antibody; a method for screening a substance capable of changing the expression of a gene encoding the protein; a method for screening a substance capable of changing the activity of the protein; and preventives, remedies and diagnostics for diseases induced by the acceleration or depression of protein decomposition.
