摘要 |
A method for screening a compound or its salt capable of altering the bonding properties of MCH or its salt to SLC-1 or its salt, characterized by using MCH or its derivative or its salt and SLC-1 or its salt, etc. The above screening method is useful in screening an SLC-1 agonist which is usable as appetite (eating) stimulating agents and preventives and remedies for weak pains, atonic bleeding, before and after expulsion, uterine recovery insufficiency, caesarean section, artificial interruption of pregnancy, milk congestion, etc. and an SLC-1 antagonist which is usable as antiobestic agents (drugs), appetite (eating) regulators, and preventives and remedies for excessively strong pains, tonic uterine contraction, fetal asphyxia, rupture of uterus, cervical rupture, premature birth, Prader-Willi syndrome, etc. |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
MORI, MASAAKI;SHIMOMURA, YUKIO;TAKEKAWA, SHIRO;SUGO, TSUKASA;ISHIBASHI, YOSHIHIRO;KITADA, CHIEKO;SUZUKI, NOBUHIRO |