发明名称 |
Methods and compositions for inducing tumor-specific cytotoxicity |
摘要 |
The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
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申请公布号 |
US6087164(A) |
申请公布日期 |
2000.07.11 |
申请号 |
US19980165240 |
申请日期 |
1998.10.01 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM |
发明人 |
HOCHBERG, ABRAHAM;AYESH, SUHAIL |
分类号 |
C12N15/09;A61K31/711;A61K48/00;A61P35/00;C07K14/05;C07K14/65;C12N5/10;C12N15/11;(IPC1-7):C12N15/63;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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