Process for preparing N-demethyl-N-alkyl erythromycin derivatives

摘要

The claimed invention relates to a novel process of preparing N-demethyl-N-alkyl-4''-deoxy erythromycin A and B. The process comprises protecting the 2'-hydroxy or the 2'- and 11-hydroxy of a N-demethyl-4''-deoxy erythromycin derivative having the formula: where Rb is H or OH, with a silyl protecting group and alkylating the N-position of the desosamine sugar.