Polyamine transport inhibitors

摘要

The application discloses synthetic derivatives of original polyamines in which a carbon atom to the original polyamine comprises an amide group inhibits the e cellular uptake of a natural polyamine by specifically binding a cellular transporter for a natural polyamine . The synthetic derivatives are used to inhibit the activity of a natural polyamine transporter, in the treatment of disorders involving unrestrained cell proliferation and/or differentiation where control of polyamine transport is required When used in combination with a n inhibitor of polyamine synthesis.