| 发明名称 |
Use of toxin peptides and/or affinity handles for delivering compounds into cells |
| 摘要 |
<p>A method and compositions for delivering a compound to the cytoplasm of a cell are disclosed. The compound to be delivered may be an antigenic compound, may be linked to a polycationic affinity handle, or both. In one of the methods disclosed, the B moiety of a toxin, such as the anthrax PA polypeptide, is also provided to enhance delivery of the compound to the cytoplasm of the cell.</p> |
| 申请公布号 |
AU720857(B2) |
申请公布日期 |
2000.06.15 |
| 申请号 |
AU19970022401 |
申请日期 |
1996.12.13 |
| 申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
R. JOHN COLLIER;STEVEN R. BLANKE;JILL C. MILNE;ERICKA L. LYSZAK;JIMMY D. BALLARD;MICHAEL N. STARNBACH |
| 分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K39/00;A61K39/02;A61K39/04;A61K39/112;A61K39/12;A61K39/13;A61K39/165;A61K39/20;A61K39/205;A61K39/21;A61K39/245;A61K39/25;A61K39/285;A61K39/29;A61K39/385;A61K47/48;A61K48/00;A61P31/00;A61P31/04;A61P31/12;A61P31/14;A61P31/18;A61P31/20;A61P31/22;A61P43/00;C07K14/005;C07K14/195;C07K14/32;C07K14/47;C07K19/00;C12N1/21;C12N15/87;(IPC1-7):A61K38/07;C12N5/10;C07K14/435;C07K9/00;C07K14/19;C07K14/05;C12N15/00;C12N15/12;C07K14/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
