| 摘要 |
<p>An enteric coated pravastatin bead formulation is provided which includes pravastatin, optionally a basifying agent such as MgO or CaCO3, and an enteric coating formed of a methacrylic acid copolymer which may be a methylacrylate/methacrylic acid copolymer or a methylmethacrylate/methacrylic acid copolymer, and plasticizer such as diethyl phthalate and a dusting of talc. The enteric coated formulation has good resistance to deterioration at pH less than 3, but has good drug release properties at greater than 4 and provides for increased bioavailability and increased LDL and TG lowering compared to pravastatin formulations which do not include an enteric coating and do not provide release throughout the small intestine for prolonged absorption time.</p> |
