| 发明名称 |
Antibody variants with higher binding affinity compared to parent antibodies |
| 摘要 |
Antibody variants of parent antibodies are disclosed which have one or more amino acids inserted in a hypervariable region of the parent antibody and a binding affinity for a target antigen which is at least about two fold stronger than the binding affinity of the parent antibody for the antigen. |
| 申请公布号 |
AU1728800(A) |
申请公布日期 |
2000.06.05 |
| 申请号 |
AU20000017288 |
申请日期 |
1999.11.16 |
| 申请人 |
GENENTECH INC. |
发明人 |
YVONNE M. CHEN;HENRY B. LOWMAN;YVES MULLER |
| 分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P5/14;A61P9/00;A61P9/10;A61P11/00;A61P17/06;A61P27/02;A61P27/06;A61P29/00;A61P35/00;C07K16/00;C07K16/18;C07K16/22;C07K16/24;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/13;C12P21/08 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
