发明名称 |
Process for producing 5-hydroxymethyl substituted oxazolidinone alcohols and transformation to 5 aminomethyl substituted oxazolidinone amines which are useful in production of antibacterial pharmaceuticals |
摘要 |
A process for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) as starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone. |
申请公布号 |
NZ332278(A) |
申请公布日期 |
2000.05.26 |
申请号 |
NZ19970332278 |
申请日期 |
1997.03.28 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
PEARLMAN, BRUCE A;PERRAULT, WILLIAM R;BARBACHYN, MICHAEL R;MANNINEN, PETER R;TOOPS, DANA S;HOUSER, DAVID J;FLECK, THOMAS J |
分类号 |
C07D263/20;C07D263/24;C07D295/00;C07D413/04;C07D413/10;C07D487/04;C07D521/00;(IPC1-7):C07D487/04 |
主分类号 |
C07D263/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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