| 摘要 |
PURPOSE: Provided is peritoneal dialysis and solutions for the same. More specifically, the use of atrial natriuretic peptide (ANP) as an additive to peritoneal dialysis solutions to increase the adequacy thereof is also provided. CONSTITUTION: A present invention provides an improved peritoneal dialysis solution that includes an additive in the form of atrial natriuretic peptide (ANP), an ANP derivative, an ANP analog, a substance that binds to ANP clearance receptors and therefore reduces the clearance of ANP and/or a promoter of ANP synthesis. A peritoneal dialysis solution improves the adequacy of the peritoneal dialysis conducted with the solution. When the term ANP is used below, it is intended to encompass the ANP prohormone molecule, the circulating form of ANP as well as the fragments having biological activity. The sequence of natural ANP in the human body is identified as SEQ ID NO: 1. Atrial natriuretic peptide (ANP) that is designed primarily to: (1) improve the net ultrafiltration experienced by peritoneal dialysis patients and (2) improve the clearance of sodium in peritoneal dialysis patients. Other benefits such as improved clearances of phosphorous, uremic toxins, urea nitrogen and cretinize may also be provided.
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