发明名称 |
Screening methods for presqualene diphosphate analogs |
摘要 |
The present invention is directed to presqualene diphosphate (PSDP) analogs having an active region of natural PSDP and a metabolic transformation region resistant to rapid intracellular inactivation in vivo. For example, PSDP and its stable analogs can inhibit neutrophil signal transduction events in cellular activation that result in the generation of active oxygen species, regulation of leukocyte adherence, both homotypic (leukocyte-leukocyte) or heterotypic adherence with leukocytes and epithelial cells of mucosal origin or endothelial cells of vascular origin. These analogs can also be used to regulate leukocyte-dependent tissue injury.
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申请公布号 |
US6066466(A) |
申请公布日期 |
2000.05.23 |
申请号 |
US19980055592 |
申请日期 |
1998.04.06 |
申请人 |
BRIGHAM & WOMENS HOSPITAL |
发明人 |
SERHAN, CHARLES N.;LEVY, BRUCE D. |
分类号 |
C07F9/117;C12Q1/34;G01N33/50;G01N33/68;(IPC1-7):C12Q1/34 |
主分类号 |
C07F9/117 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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