摘要 |
The present invention relates to deletion and substitution mutant polypeptides of human chemokine beta -7 (Ck beta -7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck beta -7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck beta -7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions. |
申请人 |
HUMAN GENOME SCIENCES INC.;SALCEDO, THEODORA, W.;PATEL, VIKRAM;NIBBS, ROBERT, JOHN, BENJAMIN;GRAHAM, GERARD, JOHN;LI, HAODONG;RUBEN, STEVEN, M. |
发明人 |
SALCEDO, THEODORA, W.;PATEL, VIKRAM;NIBBS, ROBERT, JOHN, BENJAMIN;GRAHAM, GERARD, JOHN;LI, HAODONG;RUBEN, STEVEN, M. |