| 摘要 |
A method for cleaving polypeptides includes contacting a polypeptide with a recombinant or isolated Kell protein having proteolytic activity for the polypeptide. A method for converting big endothelins-1, -2 and -3 to endothelins-1, -2 and -3 respectively comprises contacting the big endothelin with Kell protein having proteolytic activity for cleaving big endothelin-1, -2 and -3 to endothelin-1, -2 or -3 respectively. In another embodiment, the Kell protein cleaves vasoactive intestinal peptide.
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