PERFLUORO-1H-1H-NEOPENTYL-ENTHALTENDES KONTRASTMITTEL UND VERFAHREN ZU SEINER VERWENDUNG

摘要

Organic compounds for diagnostic imaging which contain at least one aryl group which has been derivatized to contain at least one perfluoro-1H,1H-neopentyl moiety are provided. The perfluoro-1H,1H-neopentyl groups produce a single magnetic resonance to insure a maximum signal to noise ratio. One compound disclosed is 2-O-oleoylglycerol 1,3-bis(7'-{3'',5''-di[2''',2'''-di(trifluoromethyl)3''', 3''',3'''-trifluoropropyl]phenyl}heptanoate). In the preferred embodiment, a lipid emulsion is provided as a carrier vehicle to deliver the derivitized analog to a mammalian recipient. Methods to use these compounds in MRI and computerized tomography are provided.